Regular ArticleRH blood group system and molecular basis of Rh-deficiency
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2022, BloodCitation Excerpt :Similarly, Goa+ iRBCs specifically showed strong (4+) agglutination when incubated with patient plasma containing a previously identified anti-Goa, whereas Rh null, D--, DAK+, and VVS+ iRBCs showed no agglutination. Individuals with Rh null phenotypes caused by inactivating mutations in RHAG, which is involved in cation transport and facilitates cell surface Rh expression, have mild hemolytic anemia and RBCs with stomatocyte morphology.23,24 The transporter function of RhAG motivated the generation of Rh null iPSCs here by disrupting the RHCE alleles rather than RHAG as by others.25,26
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2018, Noninvasive Prenatal Testing (NIPT): Applied Genomics in Prenatal Screening and DiagnosisA novel nonsense mutation in RHAG gene responsible for Rh<inf>null</inf> phenotype in a Chinese individual
2017, Transfusion and Apheresis ScienceCitation Excerpt :The amorph type is the result of mutations inactivating RH lotus, whereas the regulator type is apparently caused by mutations at a separate suppressor gene modulating Rh-antigen expression [2]. RhAG is critically required for the correct assembly of the Rh proteins in the red cell membrane, so defects in RHAG gene can cause the regulator type of Rhnull phenotype [3]. Inactivation of RHAG gene is caused by a variety of genetic mechanisms including point mutations, and splice site mutations.
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