Best Practice & Research Clinical Haematology
Volume 23, Issue 1 , Pages 61-69 , March 2010

Clinical and diagnostic implications of monoclonal B-cell lymphocytosis

  • Andy C. Rawstron, PhD (Professor, Consultant Clinical Scientist)

      Affiliations

    • Haematological Malignancy Diagnostic Service (HMDS), St. James's Institute of Oncology, Bexley Wing, Beckett Street, Leeds LS9 7TF, UK
    • Hull York Medical School (HYMS), University of York, YO10 5DD, UK
  • ,
  • Peter Hillmen, PhD, MD (Consultant Haematologist)

      Affiliations

    • Department of Haematology, St. James’s Institute of Oncology, Bexley Wing, Beckett Street, Leeds LS9 7TF, UK
    • Corresponding Author InformationCorresponding author.

References 

  1. Abrisqueta P, Pereira A, Rozman C, et al. Improving survival in patients with chronic lymphocytic leukemia (1980–2008): the Hospital Clinic of Barcelona experience. Blood. 2009 Sep 3;114(10):2044–2050
  2. Molica S, Levato D. What is changing in the natural history of chronic lymphocytic leukemia?. Haematologica. 2001;86(1):8–12
  3. Shanafelt TD, Bowen D, Venkat C, et al. Quality of life in chronic lymphocytic leukemia: an international survey of 1482 patients. Br J Haematol. 2007 Oct;139(2):255–264
  4. Marti GE, Rawstron AC, Ghia P, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol. 2005;130(3):325–332
  5. Ghia P, Prato G, Scielzo C, et al. Monoclonal CD5+ and CD5-B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood. 2004;103(6):2337–2342
  6. Rawstron AC, Green MJ, Kuzmicki A, et al. Monoclonal B lymphocytes with the characteristics of ‘indolent’ chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood. 2002;100(2):635–639
  7. Nieto WG, Almeida J, Romero A, et al. Increased frequency (12%) of circulating CLL-like B-cell clones in healthy individuals using a high-sensitive multicolor flow cytometry approach. Blood. 2009;[Internet]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19420353
  8. Rawstron AC, Bennett F, Hillmen P. The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia. Br J Haematol. 2007;139(5):724–729
  9. Rawstron AC, Bennett FL, O’Connor SJ, et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008;359(6):575–583
  10. Shanafelt TD, Kay NE, Jenkins G, et al. B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. Blood. 2009 Apr 30;113(18):4188–4196
  11. Stamatopoulos K, Belessi C, Moreno C, et al. Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations. Blood. 2007;109(1):259–270
  12. Dagklis A, Fazi C, Sala C, et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood. 2009;114(1):26–32
  13. Fung SS, Hillier KL, Leger CS, et al. Clinical progression and outcome of patients with monoclonal B-cell lymphocytosis. Leuk Lymphoma. 2007;48(6):1087–1091
  14. Mulligan CS, Thomas ME, Mulligan SP. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008;359(19):2065–2066author reply 2066
  15. Shanafelt TD, Kay NE, Rabe KG, et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol. 2009 Aug 20;27(24):3959–3963
  16. Rossi D, Sozzi E, Puma A, et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol. 2009;[Internet]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19438485
  17. Shanafelt TD. Predicting clinical outcome in CLL: how and why. Hematology Am Soc Hematol Educ Program. 2009;421–429
  18. Rawstron AC, Jones RA, Ferguson C, et al. Outreach monitoring service for patients with indolent B-cell and plasma cell disorders: a UK experience. Br J Haematol. 2007;139(5):845–848
  19. Herrick JL, Shanafelt TD, Kay NE, et al. Monoclonal B-cell lymphocytosis (MBL): A bone marrow study of an indolent form of chronic lymphocytic leukemia (CLL). Mod Pathol. 2008;21:1173
  20. Rachel JM, Zucker ML, Fox CM, et al. Monoclonal B-cell lymphocytosis in blood donors. Br J Haematol. 2007;139(5):832–836
  21. Marti GE, Carter P, Abbasi F, et al. B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2003;52(1):1–12
  22. Rawstron AC, Yuille MR, Fuller J, et al. Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood. 2002;100(7):2289–2290
  23. de Tute R, Yuille M, Catovsky D, et al. Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults. Leukemia. 2006;20(4):728–729
  24. Del Giudice I, Mauro FR, De Propris MS, et al. Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients. Blood. 2009 Sep 24;114(13):2848–2849
  25. Matos DM, Ismael SJ, Scrideli CA, et al. Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Br J Haematol. 2009 Nov;147(3):339–346
  26. Hardy NM, Grady C, Pentz R, et al. Bioethical considerations of monoclonal B-cell lymphocytosis: donor transfer after haematopoietic stem cell transplantation. Br J Haematol. 2007;139(5):824–831
  27. Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?. J Clin Oncol. 2008 Sep 20;26(27):4497–4503
  28. Majhail NS. Old and new cancers after hematopoietic-cell transplantation. Hematology Am Soc Hematol Educ Program. 2008;142–149
  29. Amato D, Oscier DG, Davis Z, et al. Cytogenetic aberrations and immunoglobulin VH gene mutations in clinically benign CD5- monoclonal B-cell lymphocytosis. Am J Clin Pathol. 2007 Aug;128(2):333–338
  30. Rawstron AC, Villamor N, Ritgen M, et al. International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia. 2007 May;21(5):956–964
  31. Swerdlow S, Campo E, Harris N, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. WHO Press; 2008;

PII: S1521-6926(10)00010-1

doi: 10.1016/j.beha.2010.02.002

Best Practice & Research Clinical Haematology
Volume 23, Issue 1 , Pages 61-69 , March 2010