Should double cord blood transplants be the preferred choice when a sibling donor is unavailable?

References 

1. Eapen M, Rubinstein P, Zhang MJ, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–1954
   • Abstract
   • Full Text
   • Full-Text PDF (125 KB)
   • CrossRef
2. Kurtzberg J, Prasad VK, Carter SL, et al. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008;112:4318–4327
   • CrossRef
3. Eapen M, Rocha V, Scaradavou A, et al. Effect of stem cell source on transplant outcomes in adults with acute leukemia: a comparison of unrelated bone marrow (BM), peripheral blood (PB) and cord blood (CB). Blood. 2008;112:62;(abstr 151)
4. Barker JN, Weisdorf DJ, DeFor TE, et al. Non-myeloablative umbilical cord blood transplantation (UCBT): low transplant-related mortality in 59 high-risk adults. Blood. 2004;104:235a;(abstr 825)
5. Brunstein CG, Barker JN, DeFor TE, et al. Non-myeloablative (NMA) umbilical cord blood transplantation (UCBT): promising disease-free survival in 95 consecutive patients. Blood. 2005;106:166a;(abstr 559)
6. Rio B, Blaise D, Renaud M, et al. Cord blood transplantation after non myeloablative conditioning (Minneapolis protocol): impact on transplant outcomes in 112 adults with hematologic malignancy. A French multicentric study of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) and Eurocord. Blood. 2007;110:604a;(abstr 2029)
7. Rodrigues CA, Brunstein C, Sanz G, et al. Cord blood transplantation from unrelated donors for adults with advanced lymphoid malignancies – A Eurocord-Netcord Group/EBMT-LWP study. Blood. 2007;110:603a;(abstr 2025)
8. No authors listed . Singe versus double umbilical cord blood transplantation in children with high risk leukemia and myelodysplasia (BMT CTN 0501). Available from: http://clinicaltrials.gov/ct2/show/NCT00412360[accessed 07.01.09]