Best Practice & Research Clinical Haematology
Volume 22, Issue 4 , Pages 495-499, December 2009

Thrombopoietin in normal and neoplastic stem cell development

University of California San Diego Medical Center, 402 Dickinson Street, Suite 380, San Diego, CA 92103-8811, USA

It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.

Keywords: thrombopoietin, stem cell, myeloproliferative disorders, c-MPL, JAK2, HOX

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PII: S1521-6926(09)00058-9

doi:10.1016/j.beha.2009.08.004

Best Practice & Research Clinical Haematology
Volume 22, Issue 4 , Pages 495-499, December 2009

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