Best Practice & Research Clinical Haematology
Volume 21, Issue 1 , Pages 93-98, March 2008

Are there effective new strategies for the treatment of acute and chronic GvHD?

  • Nelson J. Chao, MD, MBA (Professor of Medicine and Immunology)

      Affiliations

    • Corresponding Author InformationTel.: +1 919 668 1010; Fax: +1 919 668 1091.

Division of Cellular Therapy/BMT, Duke University, 2400 Pratt Street, Suite 9011, Box 3961, Durham, NC 27710, USA

The molecular biology and pathophysiology underlying graft-versus-host disease (GvHD) remains an area of intensive research. Understanding normal and abnormal developments of both the innate and adaptive immune systems are beginning to provide understanding of the details of relevant pathways. Recent work in gene-expression profiling suggests a critical next step in identifying broader patterns that will stand up to examination in independent data sets and provide a sturdy basis for targeted therapy and preventive measures against GvHD.

Key words: acute graft-versus-host disease, chronic graft-versus-host disease, GvHD, gene expression profiling

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PII: S1521-6926(07)00103-X

doi:10.1016/j.beha.2007.11.012

Best Practice & Research Clinical Haematology
Volume 21, Issue 1 , Pages 93-98, March 2008

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