Best Practice & Research Clinical Haematology
Volume 21, Issue 1 , Pages 21-28 , March 2008

Has gene expression profiling improved diagnosis, classification, and outcome prediction in AML?

  • Cheryl L. Willman, MD (The Maurice and Marguerite Liberman Distinguished Chair in Cancer Research Director & CEO)

      Affiliations

    • Corresponding Author InformationTel.: +1 505 272 5622; Fax: +1 505 272 4039.

References 

  1. Ross ME, Mahfouz R, Onciu M, et al. Gene expression profiling of pediatric acute myelogenous leukemia. Blood. 2004;104:3679–3687
  2. Valk PJ, Verhaak RG, Beijen MA, et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. The New England Journal of Medicine. 2004;350:1617–1628
  3. Bullinger L, Dohner K, Bair E, et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. The New England Journal of Medicine. 2004;350:1605–1616
  4. Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. The New England Journal of Medicine. 2005;352:254–266
  5. Verhaak RG, Goudswaard CS, van PW, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005;106:3747–3754
  6. Wilson CS, Davidson GS, Martin SB, et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood. 2006;108:685–696
  7. Davidson GS, Hendrickson B, Johnson DK, et al. Knowledge mining with VxInsight: Discovery through interaction. Journal of Intelligent Information Systems. 1998;11:259–285
  8. Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. Journal of Clinical Oncology. 2005;23:7332–7341
  9. Radmacher MD, Marcucci G, Ruppert AS, et al. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood. 2006;108:1677–1683

PII: S1521-6926(07)00098-9

doi: 10.1016/j.beha.2007.11.008

Best Practice & Research Clinical Haematology
Volume 21, Issue 1 , Pages 21-28 , March 2008

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