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Best Practice & Research Clinical Haematology
Volume 20, Issue 4
, Pages 701-715
, December 2007
Bortezomib in multiple myeloma
References
- . Múltiple Myeloma. The New England Journal of Medicine. 2004;351(18):1860–1873
- Proteasome inhibitors: a novel of potent and effective antitumor agents. Cancer Research. 1999;59:2615–2622
- . The proteasome; a suitable antineoplastic target. Nature Reviews Cancer. 2004;4:349–360
- . The ubiquitin-proteasome proteolytic pathway; destruction for the sake of construction. Physiological Reviews. 2002;82:373–428
- Structure of 20S proteasome from yeast at 2.4 A resolution. Nature. 1997;386:463–471
- . The proteasome and proteasome inhibitors in cancer therapy. Annual Review of Pharmacology and Toxicology. 2006;46:189–213
- Thalidomide and new drugs for treatment of multiple myeloma. The Hematology Journal. 2003;4:201–207
- Proteasome inhibition as a therapeutic strategy for hematologic malignancies. Expert Review of Anticance Therapy. 2005;5:465–476
- The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Research. 2001;61:3071–3076
- Proteasome inhibitor disrupt the unfolded protein response in myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 2003;100:9946–9951
- Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent down regulation of gp130 in multiple myeloma. Oncogene. 2003;22(52):8386–8393
- Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Research. 2002;62(17):4996–5000
- A Phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumour malignancies. Clinical Cancer Research. 2002;8:2505–2511
- Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. Journal of Clinical Oncology. 2002;20:4420–4427
- Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumours with observations in androgen-independent prostate cancer. Journal of Clinical Oncology. 2004;22:2108–2121
- . Development of the proteasome inhibitor PS-341. Oncologist. 2002;7(1):9–16
- Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. Drug Metabolism and Disposition. 2005;33:771–777
- A phase 2 study of bortezomib in relapsed, refractory myeloma. The New England Journal of Medicine. 2003;348(26):2609–2617
- A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. British Journal of Haematology. 2004;127(2):165–172
- Bortezomib or High-dose dexamethasone for relapsed multiple myeloma. The New England Journal of Medicine. 2005;352:2487–2498
- Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia. 2007;21:151–157
- The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumour cells to chemotherapeutic agents. Clinical Cancer Research. 2003;9(3):1136–1144
- The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood. 2003;101:2377–2380
- Phase I trial of the proteasome inhibitor Bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood. 2005;105:3058–3065
- Randomized Phase III study of pegilated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol. 2007;25:3892–3901
- Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. Journal of Clinical Oncology. 2006;24(6):937–944
- A Phase I/II Trial of bortezomib, low dose intravenous melphalan and dexamethasone for patients with relapsed multiple myeloma. Blood. 2006;108(11):3542;Abstract
- A phase i–ii trial of bortezomib plus oral cyclophosphamide and prednisone for relapsed/refractory multiple myeloma. Blood. 2006;108(11):3536;Abstract
- Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma. Br J Haematol. 2007;138:330–337
- The combination of cyclophosphamide, velcade and dexamethasone (VCD) induces high response rate and comparable toxicity compared to velcade alone and velcade plus dexamethasone. Haematologica. 2007;92:1149–1150
- Velcade (V)–thalidomide (T)–dexamethasone (D) for advanced and refractory multiple myeloma (MM): long-term follow-up of phase I–II trial UARK 2001-37: Superior outcome in patients with normal cytogenetic and no prior T. Blood. 2005;106:2552;Abstract
- Bortezomib (velcadeTM) + adriamycinTM + thalidomide + dexamethasone (VATD) as an effective regimen in patients with refractory or relapsed multiple myeloma (MM). Blood. 2004;104(11):2399;Abstract
- . Velcade, Doxil and Thalidomide (VDT) is an effective salvage regimen for patients with relapsed and refractory multiple myeloma. Leukemia and Lymphoma. 2005;46(7):1103–1104
- Bortezomib, melphalan, prednisone and thalidomide for relapsed multiple myeloma. Blood. 2007;109:2767–2772
- The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide (VMDT) is an effective regimen for relapsed/refractory myeloma and reduces serum levels of Dickkopf-1, RANKL, MIP-1α and angiogenic cytokines. Blood. 2006;108(11):3541;Abstract
- Bortezomib and lenalidomide plus (Vel-Rev) in relapsed and/or refractory multiple myeloma (MM): final results of a multicenter phase 1 trial. Blood. 2006;108(11):404;Abstract
- Phase II trial of single agent bortezomib (VELCADE®) in patients with previously untreated multiple myeloma (MM). Blood. 2004;104(11):336;Abstract number
- Single agent bortezomib is associated with a high response rate in patients with high risk myeloma. A Phase II study from the Eastern Cooperative Oncology Group (E2A02). Blood. 2006;108(11):3527;Abstract
- Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. British Journal of Haematology. 2005;129:776–783
- Long-term follow-up of patients treated with bortezomib alone and in combination with dexamethasone as frontline therapy for multiple myeloma. Blood. 2006;108(11):796;Abstract
- Bortezomib (VELCADE®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation (ASCT) in patients with newly diagnosed multiple myeloma: preliminary results of an IFM phase II study. Hematologica. 2006;91(11):1498–1505
- VELCADE/dexamethasone (Vel/Dex) Versus VAD as induction treatment prior to autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma (MM): an interim analysis of the IFM 2005-01 randomized multicenter phase III trial. Blood. 2006;108(11):56;Abstract
- Phase II Pethema trial of alternating bortezomib and dexamethasone as induction regimen before autologous stem cell transplantation in younger patients with Multiple Myeloma: Efficacy and clinical implications of tumor response kinetics. J Clin Oncol. 2007;25(28):4452–4458
- PAD combination therapy (PS-341/bortezomib, adriamycin and dexamethasone) for previously untreated patients with multiple myeloma. British Journal of Haematology. 2005;129:755–762
- Reduced dose PAD combination therapy (PS-341/bortezomib, adriamycin and dexamethasone) for previously untreated patients with multiple myeloma. Blood. 2005;106(11):717;Abstract
- High rate of complete and near complete responses (CR/nCR) after initial therapy with bortezomib (Velcade®), Doxil®, and dexamethasone (VDD) is further increased after autologous stem cell transplantation (ASCT). Blood. 2006;108(11):3096;Abstract
- Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma. Hematology. 2007;12(3):235–239
- Phase I trial of first-line bortezomib/thalidomide plus chemotherapy for induction and stem cell mobilization in patients with multiple myeloma. Clinical Lymphoma and Myeloma. 2006;7(3):210–216
- Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase I/II trial. Blood. 2006;108:2165–2172
- . VelcadeTM (bortezomib) for injection. Prescribing information. Cambridge, MA: Millennium Pharmaceuticals, Inc.; 2004;
- Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function. Cancer. 2005;103:1195–1200
- Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study. Blood. 2007;109:2604–2606
- A practical update on the use of bortezomib in the management of multiple myeloma. The Oncologist. 2006;11:51–61
- Bortezomib-induced severe hepatitis in multiple myeloma: a case report. Archives of Internal Medicine. 2005;165:464–465
- Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood. 2005;106:3777–3784
- Bortezomib-induced tumor lysis syndrome in multiple myeloma: brief communication. Clinical Lymphoma and Myeloma. 2006;7(3):233–235
PII: S1521-6926(07)00068-0
doi: 10.1016/j.beha.2007.09.003
© 2007 Elsevier Ltd. All rights reserved.
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Best Practice & Research Clinical Haematology
Volume 20, Issue 4
, Pages 701-715
, December 2007
