Best Practice & Research Clinical Haematology
Volume 20, Issue 3 , Pages 469-477, September 2007

Revision of the guidelines for diagnosis and therapy of chronic lymphocytic leukemia (CLL)

Klinik I für Innere Medizin, Universität zu Köln, Kerpenerstr. 62, D-50924 Köln, Germany

published online 28 July 2007.

During the past 10 years, significant progress has been achieved in defining new prognostic markers, diagnostic parameters, and treatment options in chronic lymphocytic leukemia (CLL). These developments have led to revision of the National Cancer Institute-sponsored Working Group (NCI-WG) guidelines on CLL established in 1988 and 1996. The update of these guidelines will clarify the role of new prognostic markers in CLL, improve the definitions of response and refractory disease, and add information on the prevention and management of infectious and autoimmune complications.

Key words: chronic lymphocytic leukemia, guidelines, diagnosis, prognosis, response criteria, minimal residual disease

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PII: S1521-6926(07)00018-7

doi:10.1016/j.beha.2007.02.002

Best Practice & Research Clinical Haematology
Volume 20, Issue 3 , Pages 469-477, September 2007

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