Best Practice & Research Clinical Haematology
Volume 19, Issue 2 , Pages 353-359 , June 2006

History of the treatment of childhood ALL: A paradigm for cancer cure

  • Joseph V. Simone, MD (Professor Emeritus of Pediatrics and Medicine, Clinical Director Emeritus)

      Affiliations

    • Corresponding Author InformationAddress: 4999 Oak Trail Drive, Dunwoody, GA 30338, USA.

References 

  1. Djerassi I, Farber S, Abir E, Neikirk W. Continuous infusion of methotrexate in children with acute leukemia. Cancer. 1967;20:233–242
  2. Skipper HE, Thomson JR, Elion GB, Hitchings GH. Observations on the anticancer activity of 6-mercaptopurine. Cancer Research. 1954;14:294–298
  3. Goldman ID. A model system for the study of heteroexchange diffusion: methotrexate–folate interactions in L1210 leukemia and Ehrlich ascites tumor cells. Biochimica et Biophysica Acta. 1971;233:624–634
  4. Shackney SE. A computer model for tumor growth and chemotherapy, and its application to L1210 leukemia treated with cytosine arabinoside (NSC-63878). Cancer Chemotherapy Reports. 1970;54:399–429
  5. Aur RJ, Simone J, Hustu HO, et al. Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood. 1971;37:272–281
  6. Hustu HO, Aur RJ, Verzosa MS, et al. Prevention of central nervous system leukemia by irradiation. Cancer. 1973;32:585–597
  7. Simone J, Pinkel D. Rationale and results of combination chemotherapy and central nervous system irradiation in acute lymphocytic leukemia. Bibliotheca Haematologica. 1973;39:1068–1073
  8. George P, Hernandez K, Hustu O, et al. A study of ‘total therapy’ of acute lymphocytic leukemia in children. Journal of Pediatrics. 1968;72:399–408
  9. Aur RJ, Simone JV, Hustu HO, et al. Cessation of therapy during complete remission of childhood acute lymphocytic leukemia. New England Journal of Medicine. 1974;291:1230–1234
  10. Pinkel D, Simone J, Hustu HO, Aur RJ. Nine years' experience with ‘total therapy’ of childhood acute lymphocytic leukemia. Pediatrics. 1972;50:246–251
  11. Simone J, Aur RJ, Hustu HO, Pinkel D. ‘Total therapy’ studies of acute lymphocytic leukemia in childhood. Current results and prospects for cure. Cancer. 1972;30:1488–1494
  12. Aur RJ, Simone JV, Hustu HO, Verzosa MS. A comparative study of central nervous system irradiation and intensive chemotherapy early in remission of childhood acute lymphocytic leukemia. Cancer. 1972;29:381–391
  13. Borella L, Green AA. Sequestration of PHA-responsive cells (T-lymphocytes) in the bone marrow of leukemic children undergoing long-term immunosuppressive therapy. Journal of Immunology. 1972;109:927–932
  14. Borella L, Sen L. T cell surface markers on lymphoblasts from acute lymphocytic leukemia. Journal of Immunology. 1973;111:1257–1260
  15. Pui CH, Cheng C, Leung W, et al. Extended follow-up of long-term survivors of childhood acute lymphoblastic leukemia. New England Journal of Medicine. 2003;349:640–649
  16. Adamson PC, Weiner SL & Simone JV (eds.). Making Better Drugs for Children with Cancer. Washington, DC: The National Academic Press, 2005.

PII: S1521-6926(05)00104-0

doi: 10.1016/j.beha.2005.11.003

Best Practice & Research Clinical Haematology
Volume 19, Issue 2 , Pages 353-359 , June 2006

Article Tools

* Image Usage & Resolution