Best Practice & Research Clinical Haematology
Volume 19, Issue 2 , Pages 353-359, June 2006

History of the treatment of childhood ALL: A paradigm for cancer cure

  • Joseph V. Simone, MD (Professor Emeritus of Pediatrics and Medicine, Clinical Director Emeritus)

      Affiliations

    • Corresponding Author InformationAddress: 4999 Oak Trail Drive, Dunwoody, GA 30338, USA.

University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, USA

The history of the treatment of childhood leukemia from 1950 to the present is reviewed here. Particular emphasis is placed on the ‘Total Therapy’ studies conducted at St Jude Children's Research Hospital in Memphis, Tennessee. Under the guidance of Donald Pinkel, MD, the first medical director of St Jude, variations in chemotherapy and craniospinal irradiation were tried, and by Study XV, begun in 2000, a 4-year event-free survival of 92±7% had been achieved. Strengths and weaknesses in the current treatment of childhood leukemia are discussed as well as possibilities for the future.

Keywords: acute leukemia, childhood cancer, leukemia therapy

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PII: S1521-6926(05)00104-0

doi:10.1016/j.beha.2005.11.003

Best Practice & Research Clinical Haematology
Volume 19, Issue 2 , Pages 353-359, June 2006

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