« Previous
Next »
Best Practice & Research Clinical Haematology
Volume 19, Issue 3
, Pages 535-569
, September 2006
Eosinophilic disorders: Molecular pathogenesis, new classification, and modern therapy
References
- . The hypereosinophilic syndromes. Ann Intern Med. 1968;68:1220–1229
- . The hypereosinophilic syndrome. Analysis of fourteen cases with review of the literature. Medicine. 1975;54:1–27
- Bain B, Pierre R, Imbert M, Vardiman JW, Brunning RD, Flandrin G. Chronic eosinophilic leukaemia and the hypereosinophilic syndrome. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization of tumours: tumours of haematopoietic and lymphoid tissues. Lyon, France; IARC Press; 2001:29-31.
- . Recent advances in pathogenesis and management of hypereosinophilic syndromes. Allergy. 2004;59:673–689
- Myelodysplastic syndrome with hypereosinophilia and a nonrandom chromosomal abnormality dic(1;7): confirmation of eosinophil clonal involvement by fluorescence in situ hybridization. Cancer Genet Cytogenet. 1998;107:65–68
- . Agar culture and chromosome analysis of eosinophilic leukaemia. J Clin Pathol. 1975;28:956–961
- . Clonality of isolated eosinophils in the hypereosinophilic syndrome. Blood. 1999;93:1651–1657
- . Clonal nature of hypereosinophilic syndrome. Blood. 1994;84:349–350
- Schoch C, Reiter A, Bursch S, et al. Chromosome banding analysis, FISH and RT-PCR performed in parallel in hypereosinophilic syndrome establishes the diagnosis of chronic eosinophilic leukemia in 22% of cases: a study on 40 patients. Blood. 2004;104:671a [abstract].
- CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib therapy. Blood. 2003;102:3093–3096
- FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia. Haematologica. 2004;89:871–873
- Lemery SJ, Robyn JA, McCoy P, et al. Lineage analysis of the FIP1L1-PDGFRa fusion gene in myeloproliferative hypereosinophilic syndrome. Blood. 2004;104:670a-671a [abstract].
- . A case of T-cell lymphoma accompanying marked eosinophilia, chronic eosinophilic pneumonia and eosinophilic pleural effusion. A case report. Tumori. 1991;77:527–530
- . Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor. Ann Hematol. 1995;71:313–314
- The association of eosinophilia with lymphoblastic leukaemia or lymphoma: a study of seven patients. Br J Haematol. 1980;45:523–534
- . Hypereosinophilic syndrome evolving to acute lymphoblastic leukemia. Int J Hematol. 1991;54:231–239
- . Cytogenetic and molecular genetic aspects of eosinophilic leukaemias. Br J Haematol. 2003;122:173–179
- Gotlib J. Molecular classification and pathogenesis of eosinophilic disorders: 2005 update. Acta Haematol. 2005; 114: 7–25.
- Heterogeneity of response to imatinib-mesylate (glivec) in patients with hypereosinophilic syndrome: implications for dosing and pathogenesis. Leuk Lymphoma. 2004;45:1219–1222
- Clinical and molecular features of FIP1L1-PDGFRA (+) chronic eosinophilic leukemias. Leukemia. 2004;18:734–742
- . Trisomy 7 and 8 in Ph-negative chronic eosinophilic leukemia. Cancer Genet Cytogenet. 1985;17:159–164
- . Ph1-negative eosinophilic leukemia with trisomy 8. Scand J Haematol. 1977;18:413–420
- Tavares de Castro J. Hibbin JA. Chromosome and cell culture studies in eosinophilic leukaemia. Br J Haematol. 1986;62:659–669
- Myelofibrosis in a child suffering from a hypereosinophilic syndrome with trisomy 8: response to corticotherapy. Med Pediatr Oncol. 1991;19:62–65
- Hypereosinophilic syndrome in childhood: trisomy 8 and transformation to mixed acute leukaemia. Nouv Rev Fr Hematol. 1994;35:555–559
- Eosinophilic leukaemia with trisomy 8 and double gammopathy. J Clin Pathol. 1993;48:672–673
- . Alpha-interferon and hypereosinophilic syndrome with trisomy 8: karyotypic remission. Blood. 1995;85:2284–2285
- The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia. Hum Pathol. 1999;30:864–868
- Imatinib therapy for hypereosinophilic syndrome and other eosinophilic disorders. Blood. 2003;101:3391–3397
- Effective treatment of hypereosinophilic syndrome with imatinib mesylate. Leuk Res. 2003;4:410–412
- . Karyotypic evolution in a granulocytic sarcoma developing in a myeloproliferative disorder with a novel (3;4) translocation. Br J Haematol. 1995;90:462–464
- . A myeloproliferative disorder with eosinophilia associated with a unique translocation (3;5). Br J Haematol. 1996;95:524–526
- . Chronic myeloid leukemia associated hypereosinophilic syndrome with a clonal t(4;7)(q11;q32). Cancer Genet Cytogenet. 1997;94:91–94
- . Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration. Ann Hematol. 2000;79:95–98
- . Imatinib-mesylate for all patients with hypereosinophilic syndrome. Leuk Res. 2004;28:773–774
- . t(5;9)(q11;q34): a novel familial translocation involving Abelson oncogene and association with hypereosinophilia. J Pediatr Hematol Oncol. 2003;25:82–84
- . Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia. Leuk Res. 2003;27:883–885
- . Association of inversion 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. N Eng J Med. 1983;309:630–636
- . 21 translocation in acute granulocytic leukemia: cytological, cytochemical, and clinical features. Br J Haematol. 1984;56:199–213
- . A case of monosomy-7 eosinophilic leukemia and neurofibromatosis, terminated with disseminated cryptococcosis. Korean J Intern Med. 1987;2:131–134
- . Acute myelogenous leukemia with eosinophilic differentiation and trisomy-1. Am J Clin Pathol. 1988;90:464–469
- Acute eosinophilic leukemia with a translocation (10p+;11q-). Cancer Genet Cytogenet. 1986;1:327–333
- . Acute myelomonocytic leukemia type M4 with bone marrow eosinophilia and t(5;16)(q33;q22). Cancer Genet Cytogenet. 1986;20:187–188
- . Broeckaert-Van Orshoven A. Van den Berghe H. Acute nonlymphoblastic leukemia with bone marrow eosinophilia and structural anomaly of chromosome 16. Cancer Genet Cytogenet. 1985;17:359–363
- Steroid-responsive pulmonary disorders associated with myelodysplastic syndromes with der(1q;7p) chromosomal abnormality. Am J Hematol. 1995;50:110–115
- . receptor tyrosine kinases: role in leukaemogenesis. Br J Haematol. 2002;116:744–757
- Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature. 1986;323:226–232
- . Cellular distribution of platelet-derived growth factor, transforming growth factor-beta, basic fibroblast growth factor, and their receptors in normal bone marrow. Acta Haematol. 2000;104:151–157
- . Mechanism of action and in vivo role of platelet-derived growth factor. Physiolog Rev. 1999;79:1283–1316
- . Platelet-derived growth factor receptor signals. J Biol Chem. 1994;269:32023–32026
- . Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta. 1998;1378:F79–F113
- Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains. Oncogene. 1998;16:505–515
- . STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene. 1999;18:3583–3592
- A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201–1214
- Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77:307–316
- Fusion of the platelet-derived growth factor beta receptor to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood. 1997;90:4271–4277
- Fusion of Huntington interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). Blood. 1998;91:4419–4426
- H4/D10S170, a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22). Blood. 2001;97:3910–3918
- Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL negative myeloproliferative disorders with a t(5;10)(q33;q21). Cancer Res. 2000;60:3592–3598
- Rabaptin-5 is a novel fusion partner to platelet-derived growth factor receptor beta in chronic myelomonocytic leukemia. Blood. 2001;98:2518–2525
- Novel translocations that disrupt the platelet-derived growth factor receptor beta (PDGFRB) gene in BCR-ABL-negative chronic myeloproliferative disorders. Br J Haematol. 2003;120:251–256
- Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood. 2003;102:4187–4190
- HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). Cancer Res. 2004;64:2649–2651
- NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res. 2004;64:2673–2676
- P53-binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Cancer Res. 2004;64:7216–7219
- Ketterling RP, Knudson RA, Gilmer HCF. Discovery of 6 novel translocations involving the imatinib responsive genes PDGFRA and PDGFRB from screening 29,047 abnormal bone marrow specimens. Blood. 2004;104:793a [abstract].
- KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32). Leukemia. 2005;19:27–30
- . Myeloproliferative disorders with translocations of chromosome 5q31-5q35: role of the platelet-derived growth factor receptor beta. Acta Haematol. 2002;107:113–122
- . Transforming properties of the Huntingtin interacting protein 1 platelet-derived growth factor beta receptor fusion protein. J Biol Chem. 1999;274:22328–22336
- The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA. Hum Mol Genet. 2002;11:1391–1397
- Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: a new clinical target for STI571/Glivec. Oncogene. 2003;22:5702–5706
- Molecular and cytogenetic characterization of a novel translocation t(4;22) involving the breakpoint cluster region and platelet-derived growth factor receptor-alpha genes in a patient with atypical chronic myeloid leukemia. Genes Chromosomes Cancer. 2004;40:44–50
- . Case report: rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate. MedGenMed. 2001;3:9
- . Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet. 2002;359:1577–1578
- . Response of idiopathic hypereosinophilic syndrome to treatment with imatinib mesylate. Leuk Res. 2002;26:881–884
- Nolasco I, Carvalho S, Parreira A. Rapid and complete response to imatinib mesylate (STI-571) in a patient with idiopathic hypereosinophilia. Blood. 2002;100:346b [abstract].
- Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome. Blood. 2003;101:4714–4716
- . The FIP1 gene encodes a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. Cell. 1995;81:379–389
- FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood. 2004;104:3038–3045
- Martinelli G, Cilloni D, Ottaviani E, et al. Idiopathic hypereosinophilic syndrome (HES) with FIP1L1-PDGFRA rearrangement can be effectively treated with imatinib. Blood. 2004;104:421a [abstract].
- Martinelli G, Apperley J, Reiter A, et al. European multicenter experience on idiopathic hypereosinophilic syndrome (HES) with FIP1L1-PDGFRA rearrangement treated with imatinib. Blood. 2004;104:422a [abstract].
- Roche-Lestienne C, Soenen-Cornu V, Kahn, J-E, et al. Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics. Blood. 2004;104:671a [abstract].
- Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood. 2004;103–473-478
- Pottier P, Blanchon B, Grossi O. [Complete remission with imatinib mesylate (Glivec) of an idiopathic hypereosinophilic syndrome associated with cutaneous mastocytosis after failure of interferon-alpha]. Rev Med Interne. 2003. 24:542-546.
- Serum concentration of cardiac troponin T in patients with hypereosinophilic syndrome treated with imatinib is predictive of adverse outcomes. Blood. 2003;102:3456–3457
- . Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib. Am J Med. 2003;115:587–589
- Sustained molecular response with imatinib in a leukemic form of idiopathic hypereosinophilic syndrome in relapse after allograft. Leukemia. 2004;18:354–355
- . Unexplained hypereosinophilia and the need for cytogenetic and molecular genetic analysis. Arch Dermatol. 2004;140:584–588
- . Imatinib mesylate treatment in two patients with idiopathic hypereosinophilic syndrome. Ann Pharmacother. 2004;38:1215–1218
- Complete molecular remission of chronic eosinophilic leukemia complicated by CNS disease after targeted therapy with imatinib. Ann Hematol. 2004;83:477–480
- Imatinib mesylate can induce complete molecular remission in FIP1L1-PDGFRα-positive hypereosinophilic syndrome. Haematologica. 2004;89:236–237
- Wolf D, Gastl G, Rumpold H. [Complete remission of an idiopathic hypereosinophilic syndrome while using imatinib]. Dtsch Med Wochenschr. 2004; 129: 2104-2106.
- . Successful treatment with imatinib mesylate of hypereosinophilic syndrome (chronic eosinophilic leukemia) with myelofibrosis. Leuk Res. 2004;28(Suppl. 1):S79–S80
- Walz C, Cilloni D, Soverini S, et al. Molecular heterogeneity of the FIP1L1-PDGFRA fusion gene in chronic eosinophilic leukemia (CEL) and systemic mastocytosis with eosinophilia (SME): a study of 43 cases. Blood. 2004; 104: 667a [abstract].
- Identification of FIP1L1-PDGFRA fusion, and expression of signal transducer and activator of transcription 5 in hypereosinophilic syndrome. Zhonghua Yi Xue Za Zhi. 2004;84:1541–1544
- Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome. Leuk Lymphoma. 2004;45:2503–2507
- . Reversal of cardiac abnormalities in a young man with idiopathic hypereosinophilic syndrome using a tyrosine kinase inhibitor. Eur J Echocardiogr. 2004;5:386–390
- . Successful treatment of idiopathic hypereosinophilic syndrome with imatinib mesylate: case report. Int J Hematol. 2004;80:75–77
- Soft tissue and skeletal involvement in FIP1L1-PDGFR-alpha positive chronic eosinophilic leukemia: imatinib mesylate may induce complete molecular and imaging remission. Haematologica. 2004;89:ECR25
- Myeloid blast crisis evolving during imatinib treatment of an FIP1L1-PDGFRalpha-positive chronic myeloproliferative disease with prominent eosinophilia. Leukemia. 2004;19:286–287
- Imatinib-responsive hypereosinophilia in a patient with B cell ALL. Leuk Lymphoma. 2004;45:2497–2501
- . Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci USA. 2003;100:7830–7835
- The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia. Blood. 2004;103:2802–2805
- The FIP1L1-PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management. Blood. 2004;103:2879–2891
- Yu J, Deuel TF, Kim HR. Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta-induced phenotypic transformation. J Biol Chem. 2000; 275: 19076-19082.
- Stover EH, Chen J, Folens C et al. Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent. Proc Natl Acad Sci USA. 2006; 103: 8078–8083.
- Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002; 100: 1532-1542.
- Gain-of-function mutations in c-kit in human gastrointestinal tumors. Science. 1998;279:577–580
- . Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor. J Biol Chem. 2002;277:38627–38634
- PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708–710
- PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRA-induced myeloproliferative disease. Cancer Cell. 2003;3:459–469
- Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood. 2003;101:4660–4666
- Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: a non-random association. Br J Haematol. 1987;67:25–31
- . Prevalence, breakpoint distribution, and clinical correlates of t(5;12). Cancer Genet Cytogenet. 2004;153:170–172
- Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med. 2002;347:481–487
- Response to STI571 in chronic myelomonocytic leukemia with platelet derived growth factor beta receptor involvement: a new case report. Haematologica. 2003;88:ECR18
- A 2-year-old with atypical CML with a t(5;12)(q33;p13) treated successfully with imatinib mesylate. Leuk Res. 2004;28(Suppl. 1):S65–S69
- Font de Mora J. Hernandez JM. Imatinib mesylate elicits positive clinical response in atypical chronic myeloid leukemia involving the platelet-derived growth factor receptor beta. Blood. 2003;102:2699–2700
- Lack of response to imatinib mesylate in a patient with accelerated phase myeloproliferative disorder with rearrangement of the platelet-derived growth factor receptor beta-gene. Haematologica. 2004;89:1263–1264
- . Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor β receptor fusion oncogene. Blood. 2002;100:1088–1091
- . Eosinophilic leukemia with a t(2;5)(p23;q35) translocation. Br J Haematol. 1994;87:404–406
- . A myeloproliferative disease in two infants associated with eosinophilia and chromosome t(1;5) translocation. Br J Haematol. 1987;66:483–486
- . A case of myelodysplasia with eosinophilia having a translocation t(5;12)(q31;q13) restricted to myeloid cells but not involving eosinophils. Br J Haematol. 1994;87:57–60
- Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13). Blood. 2002;99:1776–1784
- The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene. 1996;12:265–275
- The human GRAF gene is fused to MLL iin a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Natl Acad Sci USA. 2000;97:9168–9173
- AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13a23). Proc Natl Acad Sci USA. 1999;96:14535–14540
- A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood. 2001;98:1264–1267
- Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). Genes Chromosomes Cancer. 1999;26:192–202
- . Activation of the interleukin-3 gene by chromosome translocation in acute lymphoblastic leukemia with eosinophilia. Blood. 1990;76:285–289
- . Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13) and ETV6-ABL gene rearrangement: case report and review of the literature. Cancer Genet Cytogenet. 2002;138:139–142
- Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia. Haematologica. 2002;87:789–794
- The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood. 1999;94:4370–4373
- Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12). Blood. 2001;97:1050–1055
- Reiter A, Walz C, Watmore A et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res. 2005; 65: 2662--2667.
- . The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. Acta Haematol. 2002;107:101–107
- Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13). Proc Natl Acad Sci USA. 1998;95:5712–5717
- Consistent fusion of ZNF198 to the fibroblast growth factor receptor 1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Blood. 1998;92:1735–1742
- The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet. 1998;7:637–642
- FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat Genet. 1998;18:84–87
- The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood. 1999;93:1381–1389
- FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood. 2000;95:1788–1796
- The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Blood. 2001;98:3778–3783
- Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosomes Cancer. 2001;32:302–310
- Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood. 2003;101:286–288
- Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. Genes Chromomosomes Cancer. 2004;40:78–83
- 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes Chromosomes Cancer. 2005;42:320–325
- Walz C, Chase A, Schoch C et al. The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1. Leukemia. 2005; 19: 1005--1009.
- Identification of four new translocations involving FGFR1 in myeloid disorders. Genes Chromosomes Cancer. 2001;32:155–163
- . The ins and outs of fibroblast growth factors. Cell. 1994;78:547–552
- Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation. J Biol Chem. 1999;274:26922–26930
- ZNF198-FGFR1 transforms Ba/F3 cells to growth factor independence and results in high level tyrosine phosphorylation of STATs 1 and 5. Neoplasia. 1999;1:349–355
- Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004;5:287–298
- PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004;101:14479–14484
- . Eosinophilia. New Engl J Med. 1998;338:1592–1600
- . Velu T,Goldman M. Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. N Engl J Med. 1994;330:535–538
- Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia. J Exp Med. 1996;183:1071–1082
- CD4+T-cell population able to secrete large amounts of interleukin-5. Blood. 1996;87:1416–1422
- Receptor-independent activation of clonal Th2 cells associated with chronic hypereosinophilia. Blood. 1999;94:994–1002
- The hypereosinophilic syndrome associated with CD4+CD3- helper type 2 (Th2) lymphocytes. Leuk Lymphoma. 2001;42:123–133
- . Abnormal clones of T cells producing interleukin-5 in idiopathic hypereosinophilia. N Eng J Med. 1999;341:1112–1120
- CD3-CD4+ cells with a Th2-like pattern of cytokine production in the peripheral blood of a patient with cutaneous T cell lymphoma. Leukemia. 1997;11:1983–1985
- Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome. Br J Haematol. 2000;109:540–548
- Eosinophilia associated with clonal T-cell proliferation. Leuk Lymphoma. 1997;27:335–342
- Hypereosinophilia with abnormal T cells, trisomy 7, and elevated TARC serum level. Haematologica. 2003;88:ECR24
- . Immunophenotypic evaluation of circulating T-cell clones in hypereosinophilic syndromes with or without abnormal CD3 and CD4 lymphocytes. Haematologica. 2004;89:238–239
- High serum thymus and activation-regulated chemokine levels in the lymphocytic variant of the hypereosinophilic syndrome. J Allergy Clin Immunol. 2002;110:476–479
- Ackerman SJ, Butterfield JH. Eosinophilia, eosinophil-associated diseases, chronic eosinophilic leukemia, and the hypereosinophilic syndromes. In Hematology, 4th Ed. Hoffman R, Benz Jr. E, Shattil SJ, Furie B, Cohen HJ, Silberstein LE, McGlave P, Eds. Churchill Livingstone, Philadelphia, 2005.
- . The eosinophilias, including the idiopathic hypereosinophilic syndrome. Br J Haematol. 2003;121:203–223
- . The idiopathic hypereosinophilic syndrome. Blood. 1994;83:2759–2779
- . NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982;97:78–92
- . Therapy of the hypereosinophilic syndrome. Ann Intern Med. 1978;89:167–172
- . Eosinophilic leukemia. Remission with vincristine and hydroxyurea. Am J Med. 1975;59:297–300
- . Response to vincristine treatment in a case of idiopathic hypereosinophilic syndrome with multiple clinical manifestations. Acta Haematol. 1984;72:21–25
- . Prolonged clinical response to vincristine treatment in two patients with hypereosinophilic syndrome. Am J Pediatr Hematol Oncol. 1992;14:348–351
- Successful cyclophosphamide therapy in recurrent eosinophilic colitis associated with hypereosinophilic syndrome. Yonsei Med J. 2002;43:267–270
- . Successful long-term control of idiopathic hypereosinophilic syndrome with etoposide. Cancer. 1991;67:2826–2827
- . Etoposide for treating the hypereosinophilic syndrome. Ann Intern Med. 1994;121:899–900
- . Cyclosporin for hypereosinophilic syndrome. Ann Hematol. 1991;62:230–231
- . Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality. Pediatrics. 1997;99:630–633
- . therapy for idiopathic hypereosinophilic syndrome. Leukemia. 1997;11:1386–1390
- . α-IFN-induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5). Haematologica. 1999;84:651–653
- . Clinical and cytogenetic remission induced by interferon-α in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocation. Am J Hematol. 1998;58:137–141
- . Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon-alpha in a case with a unique chromosomal abnormality. Br J Haematol. 1996;92:176–183
- . Response of six patients with idiopathic hypereosinophilic syndrome to interferon alpha. J Allergy Clin Immunol. 1994;94:1318–1326
- . Interferon-alpha in the idiopathic hypereosinophilic syndrome: consideration of five cases. Ann Hematol. 1998;77:161–164
- . Complete remission of hypereosinophilic syndrome after interferon-alpha therapy: report of a case and literature review. J Dermatol. 2000;27:110–115
- . Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E), and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol. 1983;131:1300–1305
- Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+T cells. J Clin Invest. 1996;97:309–315
- Eosinophils express a functional receptor for interferon alpha: inhibitory role of interferon alpha on the release of mediators. Blood. 1996;87:2354–2360
- Preclinical efficacy and safety of mepolizumab (SB—240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol. 2001;108:250–257
- Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. N Engl J Med. 2003;349:2334–2339
- Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndrome. J Allergy Clin Immunol. 2004;113:115–119
- . Safety and efficacy of the monoclonal anti-interleukin-5 antibody SCH55700 in the treatment of patients with hypereosinophilic syndrome. Blood. 2004;103:2939–2941
- Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome. Br J Haematol. 2004;127:477
- . Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome. Br J Haematol. 2004;124:558–559
- Allogeneic peripheral blood cell transplantation for hypereosinophilic syndrome with myelofibrosis. Bone Marrow Transplant. 2000;25:217–218
- . Allogeneic peripheral blood stem cell transplantation for hypereosinophilic syndrome with severe cardiac dysfunction. Bone Marrow Transplant. 1999;23:1093–1094
- Chronic eosinophilic leukemia: successful treatment with an unrelated bone marrow transplantation. Leuk Lymphoma. 1998;32:189–193
- . Hypereosinophilic syndrome: successful allogeneic bone marrow transplantation. Bone Marrow Transplant. 1995;15:647–648
- . Allogeneic bone marrow transplantation in a patient with hypereosinophilic syndrome. Am J Hematol. 1996;51:164–165
- Allogeneic bone marrow transplantation for hypereosinophilic syndrome with advanced myelofibrosis. Bone Marrow Transplant. 1997;19:741–743
- . Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome. Bone Marrow Transplant. 2002;29:457–458
- Successful non-myeloablative allogeneic transplantation for treatment of idiopathic hypereosinophilic syndrome. Br J Haematol. 2002;119:131–134
- . Hypereosinophilic syndrome with multiple organ dysfunction treated by allogeneic bone marrow transplantation. Am J Hematol. 1988;27:302–303
- Successful bone marrow transplantation for idiopathic hypereosinophilic syndrome. Br J Haematol. 1995;90:213–215
- . Multiple valvar replacement for hypereosinophilic syndrome. Cardiol Young. 2002;12:67–70
- Atrioventricular valve replacement in the idiopathic hypereosinophilic syndrome. Am J Med. 1982;73:77–81
- . Aortic and mitral valve replacement in idiopathic hypereosinophilic syndrome. Ann Thorac Surg. 1988;46:570–571
- . Hypereosinophilic heart disease. Med J Aust. 1985;143:408–410
- . Loeffler's endocarditis presenting as mitral and trucuspid stenosis. Am J Cardiol. 1977;40:438–444
- . Cine-MRI-aided endomyocardectomy in idiopathic hypereosinophilic syndrome. Ann Thorac Surg. 1996;62:1856–1858
- . The hypereosinophilic syndrome and leukapheresis. Ann Intern Med. 1979;91:650–651
- . Plasma exchange or leukapheresis in the hypereosinophilic syndrome. Ann Intern Med. 1982;96:791
- . Management of hypereosinophilic syndrome with chronic plasma- and leukapheresis. Prog Clin Biol Res. 1990;337:83–85
- . Clinical features of fifteen patients with the hypereosinophilic syndrome. Q J Med. 1983;52:1–22
- . Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis. Br J Dermatol. 1993;148:817–820
- . Neurologic dysfunction in the idiopathic hypereosinophilic syndrome. Ann Intern Med. 1985;102:109–114
- . Acute aortic thrombosis despite anticoagulant therapy in idiopathic hypereosinophilic syndrome. J R Soc Med. 1998;91:492–493
PII: S1521-6926(05)00100-3
doi: 10.1016/j.beha.2005.07.013
© 2005 Elsevier Ltd. All rights reserved.
« Previous
Next »
Best Practice & Research Clinical Haematology
Volume 19, Issue 3
, Pages 535-569
, September 2006
